Subject Guides
Original high-yield summaries mirroring the Step 1 content outline. Tick topics as you finish them and your dashboard updates automatically.
General Principles
Biochemistry & Genetics
10–13%Molecular biology, metabolism, nutrition and classical genetics — the densest low-yield-feeling section that keeps showing up in vignettes.
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Immunology
6–9%Innate and adaptive immunity, hypersensitivity, immunodeficiency and transplant rejection — heavily tested with mechanism-first questions.
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Microbiology
10–15%Bacteriology, virology, mycology and parasitology paired with antimicrobial mechanisms — the highest-volume memorization block.
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General Pathology
12–15%Cellular injury, inflammation, neoplasia and the general mechanisms that underlie every organ-system chapter.
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Pharmacology
11–15%Pharmacokinetics, autonomic drugs, toxicities and antidotes — reason from receptor to side effect rather than memorising lists.
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Biostatistics & Public Health
4–6%Study design, test characteristics, bias and ethics — fully learnable points that many candidates leave on the table.
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Organ Systems
Cardiovascular
8–10%Hemodynamics, ischemia, arrhythmia, valvular disease and antihypertensives — the single densest organ-system block.
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Respiratory
6–8%Ventilation-perfusion physiology, obstructive vs restrictive disease, and pulmonary vascular pathology.
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Renal & Urinary
5–7%Clearance, acid-base, glomerular disease and diuretics — the highest-yield calculation-heavy system.
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Gastrointestinal
6–9%Luminal GI, liver, biliary and pancreas with the embryology and anatomy that anchor the vignettes.
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Hematology & Oncology
6–9%Anemias, coagulation, leukemias and lymphomas with the chemotherapy toxicities that pair with them.
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Endocrine
5–7%Hypothalamic-pituitary axes, thyroid, adrenal and diabetes with feedback-loop reasoning.
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Musculoskeletal, Skin & Connective Tissue
6–8%Rheumatology, bone pathology, dermatology and upper- and lower-limb nerve injuries.
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Neurology & Special Senses
6–9%Neuroanatomy, stroke syndromes, neurodegeneration, seizures and the eye and ear.
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Psychiatry & Behavioral Science
6–9%Diagnostic criteria with time thresholds, substance use, and psychopharmacology side-effect profiles.
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Reproductive & Embryology
5–7%Embryologic development, the menstrual cycle, pregnancy complications and reproductive oncology.
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